Medical visualization of holographic acoustic fields distributed across a brain treatment volume

Focused ultrasound brain-access platform

Holographic precision for brain access.

HoloSoniq is developing a portable focused ultrasound platform designed to shape and control acoustic energy across distributed brain treatment volumes.

Partner with us Explore the platform

The delivery problem

Promising CNS therapies need a better route to the target.

Many promising CNS programs are limited less by therapeutic concept than by delivery. The broader vision is a universal brain-access infrastructure layer for drugs, biologics, gene therapies, cell therapies, and next-generation neurotherapeutics.

Annotated illustration of the blood-brain barrier, showing drug molecules in a blood vessel, endothelial tight junctions, astrocyte endfeet, and underlying tissue.

How it works

Three technology pillars, one deployable workflow.

Concept illustration of the three platform pillars: acoustic field shaping in the brain, microbubble acoustic feedback, and robotic positioning with optical navigation.
Concept illustration of the platform under development.
01

Acoustic holography

3D-printed holographic lenses are designed for high-fidelity volumetric beam shaping for distributed and multifocal treatment volumes.

02

Predictive control

Machine-learning models use passive cavitation signals to anticipate microbubble instability and support safer, more reproducible blood-brain barrier opening.

03

MRI-free navigation

Nonlinear acoustic feedback, optical registration, and robotic positioning are being integrated into a streamlined translational workflow.

Development status

Built from de-risked research pillars.

Publications

Peer-reviewed and preprint foundations

Advanced Science Data-driven feedback for nanotheranostic brain targeting Science Advances Closed-loop controlled focused ultrasound arXiv Acoustic holography with optimal lens topologies IEEE TBME Spatial and temporal cavitation control IEEE TMI Heterogeneous angular spectrum method Science Advances Single-cell delivery analysis Nature Communications Frequency-controlled microbubble dynamics
Patents

Protected acoustic and control architecture

Acoustic hologram registration US 12,502,558 Trans-skull focused ultrasound using acoustic holograms Machine learning control US 2026/0077356 A1 Methods to control microbubble dynamics Microbubble emission sensing US 2025/0076258 A1 Oscillatory radius estimation and acoustic emission detection Ultrasound imaging and focusing systems US 12,105,052 Core acoustic focusing IP family Ultrasound imaging and focusing methods US 2024/0402133 A1 Companion methods and system claims

What comes next

A practical path from research platform to clinical translation.

  1. Prototype integration

    Combine holographic lenses, robotic positioning, passive cavitation detection, and control software.

  2. Preclinical validation

    Run water-tank, phantom, rodent, ex vivo human-skull, and large-animal studies.

  3. Regulatory engagement

    Define safety, software, manufacturing, and performance evidence with FDA CDRH feedback.

  4. Partner deployments

    Collaborate with translational research centers, academic labs, and CNS therapeutic developers.

Collaborate

We are building with clinical, research, and industry partners.

HoloSoniq is seeking conversations with focused ultrasound researchers, CNS therapeutic developers, translational funders, research centers, and strategic medical-technology partners.

Start a conversation